GAMBARAN DERAJAT HISTOPATOLOGI PENDERITA MENINGIOMA DI MAKASSAR TAHUN 2018-2022
DOI:
https://doi.org/10.22487/htj.v10i2.1165Keywords:
Meningioma, Derajat histopatologiAbstract
Meningioma merupakan suatu neoplasma dengan pertumbuhan lambat yang berasal dari sel-sel meningotelial lapisan araknoid. Meningioma dilaporkan merupakan tumor dengan insidensi tersering di Amerika Serikat, yaitu sekitar 36% dari seluruh tumor otak. Berdasarkan WHO, histopatologik meningioma terbagi dalam derajat 1 (jinak), derajat 2 (atipikal) dan 3 (ganas). Tujuan penelitian ini untuk melihat gambaran derajat histopatologi penderita meningioma di Makassar tahun 2018-2022. Penelitian kami menggunakan metode deskriptif, yang dilakukan di Makassar dari Januari 2018 hingga Desember 2022. Pada penelitian ini yang dinilai adalah usia, jenis kelamin, lokasi tumor, dan derajat histopatologi meningioma. Analisis data menggunakan software SPSS v.20. Sebanyak 200 sampel, usia 40-60 tahun paling banyak ditemukan yaitu 124 orang (62,0%), paling banyak jenis kelamin wanita yaitu 158 orang (79,0%), lokasi meningioma paling banyak berada di cerebri yaitu 83 orang (41,5%), serta meningioma derajat 1 merupakan yang terbanyak, yaitu 179 kasus (89,5%).
References
Louis DN, Perry A, Wesseling P, et al. The 2021 WHO classification of tumors of the central nervous system: A summary. Neuro Oncol. 2021;23(8):1231-1251. doi:10.1093/neuonc/noab106
Ye W, Ding-Zhong T, Xiao-Sheng Y, Ren-Ya Z, Yi L. Factors Related to the Post-operative Recurrence of Atypical Meningiomas. Front Oncol. 2020;10(503):1-7. doi:10.3389/fonc.2020.00503
Hutasoit GA, Sari P, Rupawan IK, Salman M. Tumor Phyllodes dan Prognosisnya. Heal Tadulako J. 2022;8(3):204-213. https://doi.org/10.22487/htj.v8i3.476
Fardillah N, Miskad UA, Cangara MH, Kaelan C, Ghaznawie M. Pola Ekspresi Protein P53 pada Astrositoma Berdasarkan Grading Histopatologi. Heal Tadulako J. 2023;9(2):148-156.
Backer-Grøndahl T, Moen BH, Torp SH. The histopathological spectrum of human meningiomas. Int J Clin Exp Pathol. 2012;5(3):231-242.
Kementerian Kesehatan Republik Indonesia. Pedoman Nasional Pelayanan Kedokteran Tumor Otak. Komite Penanggulangan Kanker Nasional; 2019.
J P Patel, T R Jansari VVC. Clinicopathological study of Meningioma. Trop J Pathol Microbiol. 2019;6(1):9-17.
Perry A, Louis D., Budka H, von Deimling A, Sahm F, Rushing E. Meningioma. In: WHO Classification of Tumours of The Central Nervous System. 4th ed. International Agency for Research on Cancer (IARC); 2016:232-245.
Cossu G, Messerer M, Parker F, Levivier M, Daniel RT. Meningiomas’ Management: An Update of the Literature. Neurooncology - Newer Dev. Published online 2016:361-372. doi:10.5772/62929
Fuller GN, Burger PC. Central nervous system. In: Histology for Pathologist. 4th ed. Wolters Kluwer Health Adis (ESP); 2012.
Ogasawara C, Philbrick BD, Adamson DC. Meningioma: A review of epidemiology, pathology, diagnosis, treatment, and future directions. Biomedicines. 2021;9(3):1-23. doi:10.3390/biomedicines9030319
Domingues P, González-Tablas M, Otero Á, et al. Genetic/molecular alterations of meningiomas and the signaling pathways targeted. Oncotarget. 2015;6(13):10671-10688. doi:10.18632/oncotarget.3870
Ostrom QT, Gittleman H, Fulop J, et al. CBTRUS statistical Report: primary brain and central nervous system tumors diagnosed in the United States in 2008-2012. Neuro Oncol. 2015;17:iv1-iv62. doi:10.1093/neuonc/nov189
Wahyuhadi J, Heryani D, Basuki H. Risk of meningioma associated with exposure of hormonal contraception. A case control study. Maj Obstet Ginekol. 2018;26(1):36. doi:10.20473/mog.v26i12018.36-41
Shao Z, Liu L, Zheng Y, et al. Molecular Mechanism and Approach in Progression of Meningioma. Front Oncol. 2020;10(September):1-11. doi:10.3389/fonc.2020.538845
Goldbrunner R, Minniti G, Preusser M, et al. EANO guidelines for the diagnosis and treatment of meningiomas. Lancet Oncol. 2016;17(9):e383-e391. doi:10.1016/S1470-2045(16)30321-7
Ostrom QT, Cioffi G, Gittleman H, et al. CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2012-2016. Neuro Oncol. 2019;21:V1-V100. doi:10.1093/neuonc/noz150
Gangadhar K, Santhosh D, Fatterpekar G. Imaging Features of Intracranial Meningiomas with Histopathological Correlation: A Relook into Old Disease. Nepal J Radiol. 2013;3(1):14-32. doi:10.3126/njr.v3i1.8713
Bhat AR, Wani MA, Kirmani AR, Ramzan AU. Histological-subtypes and anatomical location correlated in meningeal brain tumors (meningiomas). J Neurosci Rural Pract. 2014;5(3):244-249. doi:10.4103/0976-3147.133568
Desai P, Patel D. A study of meningioma in relation to age, sex, site, symptoms, and computerized tomography scan features. Int J Med Sci Public Heal. 2015;5(2):331. doi:10.5455/ijmsph.2016.06102015124
Alama A, Barbieri F, Spaziante R, et al. Significance of cyclin D1 expression in meningiomas: A preliminary study. J Clin Neurosci. 2007;14(4):355-358. doi:10.1016/j.jocn.2006.04.001
Park JK. Epidemiology, pathology, clinical features, and diagnosis of meningioma. UpToDate Wolters Kluwer. Published 2023. Accessed August 7, 2022. https://www.uptodate.com/contents/epidemiology-pathology-clinical-features-and-diagnosis-of-meningioma
Lee KS, Zhang JJY, Kirollos R, Santarius T, Nga VDW, Yeo TT. A systematic review and meta-analysis of the association between cyproterone acetate and intracranial meningiomas. Sci Rep. 2022;12(1):1-11. doi:10.1038/s41598-022-05773-z
Talawo VY, Kaelan C, Miskad UA. Karakteristik klinis dan histopatologi meningioma di Makassar. Heal Tadulako J. 2023;9(1):81-86.
Kim MS, Kim KH, Lee EH, et al. Results of immunohistochemical staining for cell cycle regulators predict the recurrence of atypical meningiomas. J Neurosurg. 2014;121(5):1189-1200. doi:10.3171/2014.7.JNS132661
Goyal-Honavar A, Jayachandran R, Chacko G. Meningiomas - transition from traditional histological grading to molecular profiling in WHO CNS5: A Review. Indian J Pathol Microbiol. 2022;65(5):S83-S93. doi:10.4103/ijpm.ijpm_1085_21
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Healthy Tadulako Journal (Jurnal Kesehatan Tadulako)
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.