EKSPRESI MESENCHYMAL EPITHELIAL TRANSITION FACTOR RECEPTOR (C-MET) PADA KARSINOMA SEROSUM OVARIUM

Abstract

Ovarian cancer is the eight most common caused of death of women malignancy disease in the world. Many of cases have been found in advanced stages with metastatic. Early detection of metastatic would be helpful to perform optimal prevention and therapy in order to increase morbidity and mortality rates. Mesenchymal Epithelial Transition Factor Receptor (C-met) with its Hepatocyte growth factor/ Scatter factor ligand (SF) is a membrane receptor that stimulate cell proliferation, differentiation, motility, and invasion, through mitogenic intracellular signalling.

The purpose of this study was to evaluate the role of c-met in progression of serous ovarian car- cinoma (SOC) by histopathological grading. We did retrospective cross-sectional study to 82 samples of serous ovarian carcinoma which consist of low-grade SOC and high-grade SOC, using immunohistohemical analysis. The analysis revealed that there were no significant differences (p=0.184) between expression of c-met in low-grade SOC and high – grade SOC.

These results indicate that the expression of c-met could not be used to differentiate the histo- pathological grading in serous ovarian carcinoma.

Keywords : ovarian serous carcinoma, metastatic, C-met