The Relationship Between Age and Cerebral Small Vessel Disease on Brain MRI at Royal Taruma Hospital

1. De Silva TM, Faraci FM. Contributions of Aging to Cerebral Small Vessel Disease. Annu Rev Physiol. 2020;82:275-295. doi:10.1146/ANNUREV-PHYSIOL-021119-034338/CITE/REFWORKS

2. Pantoni L. Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges. Lancet Neurol. 2010;9(7):689-701. doi:10.1016/S1474-4422(10)70104-6

3. Wardlaw JM, Smith EE, Biessels GJ, et al. Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration. Lancet Neurol. 2013;12(8):822-838. doi:10.1016/S1474-4422(13)70124-8

4. Ghaznawi R, Geerlings MI, Jaarsma-Coes M, Hendrikse J, De Bresser J. Association of White Matter Hyperintensity Markers on MRI and Long-term Risk of Mortality and Ischemic Stroke: The SMART-MR Study. Neurology. 2021;96(17):E2172-E2183. doi:10.1212/WNL.0000000000011827;REQUESTEDJOURNAL:JOURNAL:WNL;JOURNAL:JOURNAL:WNL;WGROUP:STRING:PUBLICATION

5. Inoue Y, Shue F, Bu G, Kanekiyo T. Pathophysiology and probable etiology of cerebral small vessel disease in vascular dementia and Alzheimer’s disease. Mol Neurodegener 2023 181. 2023;18(1):46-. doi:10.1186/S13024-023-00640-5

6. Singh A, Bonnell G, De Prey J, et al. Small-vessel disease in the brain. Am Hear J plus Cardiol Res Pract. 2023;27(3). doi:10.1016/J.AHJO.2023.100277

7. Shi Y, Thrippleton MJ, Makin SD, et al. Cerebral blood flow in small vessel disease: A systematic review and meta-analysis. J Cereb Blood Flow Metab. 2016;36(10):1653-1667. doi:10.1177/0271678X16662891

8. Hachinski V, Iadecola C, Petersen RC, et al. National Institute of Neurological Disorders and Stroke-Canadian Stroke Network vascular cognitive impairment harmonization standards. Stroke. 2006;37(9):2220-2241. doi:10.1161/01.STR.0000237236.88823.47;ISSUE:ISSUE:DOI

9. Pasi M, Cordonnier C. Clinical Relevance of Cerebral Small Vessel Diseases. Stroke. 2020;51(1):47-53. doi:10.1161/STROKEAHA.119.024148;WGROUP:STRING:PUBLICATION

10. World Health Organization. Noncommunicable diseases. 2025. https://www.who.int/news-room/fact-sheets/detail/noncommunicable-diseases

11. Hulley S, Cummings S, Browner W, Grady D, Hearst N, Newman T. Estimating sample size and power. Des Clin Res. 2001;2:85.

12. Mann CJ. Observational research methods. Research design II: cohort, cross sectional, and case-control studies. Emerg Med J. 2003;20(1):54-60. doi:10.1136/EMJ.20.1.54

13. Etikan I, Musa SA, Alkassim RS. Comparison of Convenience Sampling and Purposive Sampling. Am J Theor Appl Stat 2016, Vol 5, Page 1. 2015;5(1):1-4. doi:10.11648/J.AJTAS.20160501.11

14. Fleiss JL, Tytun A, Ury HK. A Simple Approximation for Calculating Sample Sizes for Comparing Independent Proportions. Biometrics. 1980;36(2):343. doi:10.2307/2529990

15. Fazekas F, Chawluk J, Alavi A, et al. MR signal abnormalities at 1.5 T in Alzheimer’s dementia and normal aging. Am J Roentgenol. 2012;149(2):351-356. doi:10.2214/AJR.149.2.351

16. McHugh ML. The Chi-square test of independence. Biochem Medica. 2013;23(2):143-149. doi:10.11613/BM.2013.018/FULLARTICLE

17. Lahna D, Schwartz DL, Woltjer R, et al. Venous Collagenosis as Pathogenesis of White Matter Hyperintensity. Ann Neurol. 2022;92(6):992. doi:10.1002/ANA.26487

18. Fatmawati H, Pramono CA, Jauhani MA, Purwandhono A, Santosa A. Correlation of White Matter Lesions Severity and Age in Ischemic Stroke at Siloam Jember Hospital. Jember Med J. 2023;2(1):20-25. doi:10.19184/JMJ.V2I1.291

19. De Leeuw FE, De Groot JC, Oudkerk M, et al. A follow-up study of blood pressure and cerebral white matter lesions. Ann Neurol. 1999;46(6):827-833. doi:10.1002/1531-8249(199912)46:6

20. Zheng K, Wang Z, Chen X, Chen J, Fu Y, Chen Q. Analysis of Risk Factors for White Matter Hyperintensity in Older Adults without Stroke. Brain Sci 2023, Vol 13, Page 835. 2023;13(5):835. doi:10.3390/BRAINSCI13050835

21. Blinkouskaya Y, Caçoilo A, Gollamudi T, Jalalian S, Weickenmeier J. Brain aging mechanisms with mechanical manifestations. Mech Ageing Dev. 2021;200. doi:10.1016/j.mad.2021.111575

22. Ter Telgte A, Van Leijsen EMC, Wiegertjes K, Klijn CJM, Tuladhar AM, De Leeuw FE. Cerebral small vessel disease: from a focal to a global perspective. Nat Rev Neurol. 2018;14(7):387-398. doi:10.1038/s41582-018-0014-y

23. O’Brien JT, Thomas A. Vascular dementia. Lancet. 2015;386(10004):1698-1706. doi:10.1016/S0140-6736(15)00463-8

24. Gorelick PB, Scuteri A, Black SE, et al. Vascular contributions to cognitive impairment and dementia: A statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2011;42(9):2672-2713. doi:10.1161/STR.0B013E3182299496;PAGE:STRING:ARTICLE/CHAPTER

25. Szklo M, Nieto FJ. Measuring Associations Between Exposures and Outcomes.; 2014.

26. Kalaria RN, Maestre GE, Arizaga R, et al. Alzheimer’s disease and vascular dementia in developing countries: prevalence, management, and risk factors. Lancet Neurol. 2008;7(9):812-826. doi:10.1016/S1474-4422(08)70169-8

27. Halim YD, Widjaya IF. Hubungan Usia Dengan Cerebral Small Vessel Disease Pada Mri Kepala Di Rs Royal Taruma. J Muara Sains, Teknol Kedokt dan Ilmu Kesehat. 2025;9(2):1-6. doi:10.24912/5S5W1457

28. Handayani F. Hubungan Durasi Tidur Dengan Fungsi Kognitif Geriatri. Heal Tadulako J (Jurnal Kesehat Tadulako). 2019;5(3):75. doi:10.22487/j25020749.2019.v5.i3.14060

29. Setiawati D, Nuraeni I, Karimah I, Agus HR, Poltekkes B, Tasikmalaya K. Hubungan Indeks Massa Tubuh dengan Tekanan Darah Lansia di Puskesmas Kahuripan Kota Tasikmalaya. Heal Tadulako J (Jurnal Kesehat Tadulako). 2022;8(2):114-119. doi:10.22487/HTJ.V8I2.511

30. Handayani F, Bintang AK, Kaelan C. Hubungan Hipertensi, Diabetes Mellitus Dan Dislipidemia Dengan Luaran Klinis Pasien Iskemik Stroke Dengan Hipersomnia. Heal Tadulako. 2018;4(1):1-6. Accessed September 8, 2019. http://jurnal.untad.ac.id/jurnal/index.php/HealthyTadulako/article/view/10192