PENGARUH PERTAMBAHAN BERAT BADAN DAN UMUR TERHADAP KADAR IG-F SERUM IBU HAMIL
DOI:
https://doi.org/10.22487/htj.v6i1.103Keywords:
IGF-1, Pertambahan Berat Badan, ibu hamilAbstract
Status gizi ibu selama kehamilan dapat mempengaruhi kadar hormon Insulin-like growth factor 1 dalam tubuh. IGF-1 berperan dalam transpor nutrisi dari ibu ke janin melalui plasenta. Tujuan penelitian ini adalah untuk mengetahui pengaruh Pertambahan berat badan dan umur terhadap kadar IGF-1 serum ibu hamil. Jenis penelitian ini yaitu analitik korelatif dengan desain Cross sectional. Jumlah sampel sebanyak 40 orang ibu hamil trimester II di Puskesmas Andalas Kota Padang yang diambil dengan teknik Consecutive sampling. Kadar IGF-1 diukur menggunakan metode ELISA. Analisis data menggunakan uji korelasi Spearman. Hasil penelitian menunjukkan terdapat pengaruh bermakna pertambahan berat badan ibu hamil terhadap kadar Ig-f serum ibu hamil dengan nilai p=0,006 (p<0,05) dan r=0,427Kesimpulan penelitian ini adalah semakin tinggi pertambahan berat bada ibu selama hamil maka kadar serum IGF-1 pada ibu hamil cenderung akan meningkat. Disarankan kepada tenaga kesehatan untuk melakukan KIE mengenai pentingnya pertambahan berat badan ibu selama kehamilan untuk mengoptimalkan pertumbuhan dan perkembangan janin.
References
Soltani H, Smith D, Olander E. Editorial Weight, Lifestyle, and Health during Pregnancy and Beyond. Hindawi J Pregnancy. 2017;2017.
doi:10.1155/2017/4981283
Therap WE of N& DTSNM-WBN& D. Williams’ Essentials of Nutrition & Diet Therapy) Staci Nix McIntosh-Williams’ Basic Nutrition & Diet Therap.
Brett KE, Ferraro ZM, Yockell-Lelievre J, Gruslin A, Adamo KB. Maternal–Fetal nutrient transport in pregnancy pathologies: The role of the placenta. Int J Mol Sci. 2014.doi:10.3390/ijms150916153
Kementrian Kesehatan Republik Indonesia. Panduan Pelayanan Kesehatan Bayi Baru Lahir Berbasis Perlindungan Anak .
Grissa O, Yessoufou A, Mrisak I, et al. Growth factor concentrations and their placental mRNA expression are modulated in gestational diabetes mellitus: Possible interactions with macrosomia. BMC Pregnancy Childbirth. 2010. doi:10.1186/1471-2393-10-7
Black RE, Victora CG, Walker SP, et al. Maternal and child undernutrition and overweight in low-income and middle-income countries. Lancet. 2013. doi:10.1016/S0140-6736(13)60937-X
Kementerian Kesehatan RI. Penyakit Jantung Penyebab Kematian Tertinggi, Kemenkes Ingatkan Cerdik. Kementerian Kesehatan Republik Indonesia. 2017. doi:351.077 Ind r
Lewitt MS, Dent MS, Hall K. The Insulin-Like Growth Factor System in Obesity, Insulin Resistance and Type 2 Diabetes Mellitus. 2014:1561-1574.
doi:10.3390/jcm3041561
Lewitt M, Dent M, Hall K. The Insulin-Like Growth Factor System in Obesity, Insulin Resistance and Type 2 Diabetes Mellitus. J Clin Med. 2014;3(4):1561-1574. doi:10.3390/jcm3041561
Ahmid M, Perry CG, Ahmed SF, Shaikh MG. Growth hormone deficiency during young adulthood and the benefits of growth hormone replacement. Endocr Connect. 2016;5(3):R1-R11.
doi:10.1530/EC-16-0024
Nur AF. Risiko Paparan Asap Rokok, Ketuban Pecah Dini dan Plasenta Ringan Terhadap BBLR di RSU Anutapura Palu. Healthy Tadulako Journal. 2019.
Nur AF, Arifuddin A, Hermiyanti H. Faktor Risiko Plasenta Ringan Pada Ibu Bersalin di RSU Anutapura Palu. Healthy Tadulako Journal. 2018.
Åsvold BO, Eskild A, Jenum PA, Vatten LJ. Maternal concentrations of insulin-like growth factor i and insulin-like growth factor binding protein 1 during pregnancy and birth weight of offspring. Am J Epidemiol. 2011.
doi:10.1093/aje/kwr067
Lager S, Powell TL. Regulation of nutrient transport across the placenta. J Pregnancy. 2012.
doi:10.1155/2012/179827
Miese-Looy G, van den Heuvel MJ, Edwards AK, Lamarre J, Tayade C. Expression of insulin-like growth factor (IGF) family members in porcine pregnancy. J Reprod Dev. 2012. doi:10.1262/jrd.09-191K
Wali JA, de Boo HA, Derraik JGB, et al. Weekly intra-amniotic igf-1 treatment increases growth of growth-restricted ovine fetuses and up-regulates placental amino acid transporters. PLoS One. 2012. doi:10.1371/journal.pone.0037899
Welly Wagey F, Joice K. IGF-1 Levels Related to Incidence of Macrosomia. Maj Obstet Ginekol. 2013.
Rozario KS, Lloyd C, Ryan F. GH and IGF-1 Physiology In Childhood.; 2000.
Blum WF, Alherbish A, Alsagheir A, et al. The growth hormone-insulin-like growth factor-I axis in the diagnosis and treatment of growth disorders. Endocr Connect. 2018;7(6):R212-R222.
doi:10.1530/EC-18-0099
Reynolds CM, Perry JK. Manipulation of the Growth Hormone-Insulin-Like Growth Factor (GH-IGF) Axis : A Treatment Strategy to Reverse the Effects of Early Life Developmental Programming. 2017.
doi:10.3390/ijms18081729
Kucera R, Topolcan O, Pecen L, et al. Reference values of IGF1, IGFBP3 and IGF1/IGFBP3 ratio in adult population in the Czech Republic. Clin Chim Acta. 2015;444:271-277. doi:10.1016/j.cca.2015.02.036
Yang MJ, Tseng JY, Chen CY, Yeh CC. Changes in maternal serum insulin-like growth factor-I during pregnancy and its relationship to maternal anthropometry. J Chinese Med Assoc. 2013. doi:10.1016/j.jcma.2013.07.004
Saputri LA. Korelasi kadar insulin-like growth factor i (igf-i) serum maternal dengan antropometri bayi baru lahir. J Ilmu Keperawatan dan Kebidanan. 2017. doi:10.26751/jikk.v8i2.294
Aimaretti G, Boschetti M, Corneli G, et al. Normal age-dependent values of serum insulin growth factor-i: results from a healthy italian population. J Endocrinol Invest. 2008. doi:10.1007/BF03346389
Behringer V, Wudy SA, Blum WF, et al. Sex differences in age-related decline of urinary insulin-like growth factor-binding protein-3 levels in adult bonobos and chimpanzees. Front Endocrinol (Lausanne). 2016.
doi:10.3389/fendo.2016.00118
Schmidt S, Joost HG, Schürmann A. GLUT8, the enigmatic intracellular hexose transporter. Am J Physiol - Endocrinol Metab. 2009.
doi:10.1152/ajpendo.91019.2008
Karima K, Achadi EL. Status Gizi Ibu dan Berat Badan Lahir Bayi. Kesmas Natl Public Heal J. 2012 ; 7(3) : 111. doi:10.21109/kesmas.v7i3.57
Greenstein B. At a Glance Sistem Endokrin.; 2007.
